[above] Sometimes what you see (or think others will see) is more important than what you measure. The upper line of text shows normal letterspacing. The lower line shows that some adjacent vertical letters benefit from increased spacing, and that adjacent round letters, which diverge from their closest points, look better with less spacing.
[above] The upper line has normal letterspacing. The lower line looks better because letterspacing was decreased ("kerned") to compensate for the diverging letterforms.
[above] Parentheses and brackets may be too low to look right in large sizes. Change the vertical alignment (within Font settings in Word). There is probably no need to do this in text sizes.
[above] You may have to add additional space to keep a letter, number or symbol from crashing into a parentheses or bracket. Height and spacing adjustments will vary with character, typeface, case and tilt (roman v. italic or oblique).
[above] Hyphens, em dashes and en dashes may have to be raised a bit in large type.
[above] The height and relative size of the “@” symbol varies greatly among typefaces. In large type sizes, experiment with lowering and/or enlarging the symbol so it aligns better with adjacent text.
Today's material is updated from my e-book, Typography for Independent Publishers.